Important Safety Information: Certain patients should not use CERDELGA based on their CYP2D6 metabolizer status due to an increased risk of side effects, including heart problems. Do not use CERDELGA if you are an Extensive Metabolizer (EM) taking a medicine that is a strong or moderate CYP2D6 inhibitor along with another medicine that is a strong or... View more

How is Gaucher disease inherited?

Gaucher disease is hereditary and can affect several members of a family within
a single generation.

Nate, USA,
patient with Gaucher disease type 1 treated with Cerdelga

Gaucher inheritance

Gaucher disease is hereditary, which means that the genes for the disease are passed from one generation to the next. A person with just one gene for Gaucher disease is a carrier. Carriers do not develop the disease but can pass the gene on to their children.

Explore the instances of carriers or when Gaucher disease is present below

Gaucher disease type 1 can affect individuals of any ethnicity

GD1 is pan-ethnic, and occurs in 1 in 40,000 in the general population

Pan-ethnic, and occurs in ~1 in 40,000 in the general population

GD1 is more common in people of Ashkenazi Jewish ancestry

More common in people of
Ashkenazi Jewish ancestry

90% American Jews are Ashkenazi

American Jews are Ashkenazi

  • In fact, the incidence of Gaucher disease in the Ashkenazi population is higher than the incidence of blood cancers, which is ~1 in 2,500.
  • In patients of Ashkenazi Jewish heritage, ~1 in 15 is a carrier.

Linda and Nate, USA, patients with Gaucher disease type 1 treated with Cerdelga

Gaucher disease type 1 patients