Cerdelga is a capsule taken by mouth either once or twice per day. Learn more
about determining your metabolizer status and dosing below.
Nate and Mike, USA,
patients with Gaucher disease type 1 treated with Cerdelga
CYP2D6 is an enzyme found in your body that plays an important role in breaking down (metabolizing) certain drugs. Your CYP2D6 metabolizer status describes how your body breaks down (metabolizes) Cerdelga.
More than 90% of adult patients tested for CYP2D6 status
are eligible for Cerdelga
Knowing your CYP2D6 metabolizer status is the first step toward determining if Cerdelga is right for you. Your doctor will perform a simple blood test known as a “genotype test” to identify what type of CYP2D6 metabolizer you are.
There are 4 main types of CYP2D6 metabolizers
|Cerdelga is indicated for:|
Your doctor will determine a specific Cerdelga dose (either once or twice daily) based on how CYP2D6 works in your body. Some people (ultra-rapid metabolizers) should not use Cerdelga because they break down the drug rapidly and may not benefit from it. A specific dosage cannot be recommended for those whose CYP2D6 metabolizer status cannot be determined (indeterminate metabolizers).
Cerdelga Eligibility: CYP2D6 Testing
CYP2D6 genotype testing is a simple test and available at no cost to patients through a Sanofi Genzyme-funded genotyping program with LabCorp.* Speak with your doctor for more information on the test or the genotyping program.
*There is no cost to the patient when the test is performed by one of 1700 LabCorp draw stations. Blood drawn at sites other than LabCorp may result in out-of-pocket expenses. LabCorp and Sanofi Genzyme are not responsible for any expenses related to out-of-pocket drug and infusion-related costs for treatment. The Sanofi Genzyme-sponsored, CYP2D6-metabolizer testing LabCorp program does not cover or provide support for the cost of MD office visits/evaluations, nursing services/observation periods, x-rays, blood work, or other testing unrelated to the specific Sanofi Genzyme LabCorp CYP2D6-metabolizer testing program, premedications/other medications, EpiPens, transportation, or other related services. Sanofi Genzyme reserves the right to make eligibility decisions, set program maximums, and rescind, revoke, or amend this program without notice.
What are the possible side effects of Cerdelga® (eliglustat)?
Cerdelga, used with certain other medicines, may cause changes in the electrical activity of your heart (ECG changes) and irregular heart beat (arrhythmias). Tell your doctor if you have new symptoms such as palpitations, fainting, or dizziness.
The most common side effects of Cerdelga include: tiredness, headache, nausea, diarrhea, and pain in the arms, legs, back, or stomach (abdomen).
Tell your health care provider about any side effect that bothers you or does not go away.
Important Information to Know
Cerdelga can affect the way other medicines work and other medicines can affect how Cerdelga works. Using Cerdelga with other medicines or herbal supplements may cause an increased risk of side effects. Your doctor may need to prescribe a different medicine, change your dose of other medicines, or change your dose of Cerdelga. Tell your doctor about any new medicines before you start taking them. Especially tell your doctor if you take:
Before taking Cerdelga, tell your doctor about all of your medical conditions, including all heart problems (including a condition called long QT syndrome), history of heart attack, and kidney or liver problems. Tell your doctor if you are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. The full important safety information and full prescribing information can provide you with additional information about Cerdelga safety considerations.
Cerdelga is a capsule taken by mouth either once or twice per day, depending on the kind of metabolizer you are, as well as other factors.If Cerdelga is right for you, you may be able to switch from an ERT 24 hours after your last infusion.
Take Cerdelga exactly as your doctor tells you to take it. Swallow the capsule whole, preferably with water, sitting upright.
DO NOT open, crush, or dissolve capsules before swallowing. If you have trouble swallowing the capsules, tell your doctor.
Cerdelga may be taken with or without food, but avoid eating or drinking grapefruit products while taking Cerdelga. Grapefruit products can increase the amount of Cerdelga in your body.
If you miss a dose of Cerdelga, take the next dose at the usual time. Do not take 2 doses of Cerdelga at the same time.